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Heterocyclic Compounds and their Biological Significance: A Review
Heterocyclic compounds form a major class of organic compounds. An enormous number of heterocyclic compounds are known today and this number is increasing rapidly due to their synthetic utility. Heterocyclic compounds dominate the field of biochemistry, medicinal chemistry, dyestuff, agricultural sciences and are of increasing importance in many other areas including polymers, adhesives and molecular engineering. Heterocyclic compounds played a vital role in the metabolism of all living cells. This review article covers the most active heterocyclic compounds that have shown substantial biological actions as antifungal, anti-inflammatory, antibacterial, antidepressant, antiulcer, antihelmintic and anticancer activity.
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A REVIEW: BIOLOGICAL SIGNIFICANCES OF HETEROCYCLIC COMPOUNDS.
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Journal of Biomolecular Structure and Dynamics
A review on medicinally important heterocyclic compounds and importance of biophysical approach of underlying the insight mechanism in biological environment.
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Heterocyclic derivatives have more interesting biological properties which hold a remarkable place in pharmaceutical industries due to their unique physiochemical properties and ease of adaption in various biological environments. Of many, the above-said derivatives have been recently examined for their promising action against a few malignancies. Specifically, anti-cancer research has benefited from these derivatives’ natural flexibility and dynamic core scaffold. In any case, concerning some other promising anti-cancer drugs, heterocyclic derivative doesn’t come without deficiencies. To be a successful drug candidate it should poses Absorption, Distribution, Metabolism and Eliminations (ADME) parameter, and must also have good binding interaction towards carrier protein as well as DNA and less in toxic nature, economically feasible. In this review, we described the overview of biologically important heterocyclic derivatives and their main application in medicine. Further, we focus types of biophysical techniques to understand the binding interaction mechanism.
Communicated by Ramaswamy H. Sarma
- Heterocyclic derivatives
- protein/DNA-drug interaction
- fluorescence spectroscopy
- computational studies
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A Review of the Biological Activities of Heterocyclic Compounds Comprising Oxadiazole Moieties
Affiliations.
- 1 Key Lab of Biofabrication of Anhui Higher Education, Hefei University, Hefei, 230601, P.R. China.
- 2 School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, P.R. China.
- 3 Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia.
- 4 Institute of Tobacoo Research, Anhui Academy of Agricultural Sciences, Hefei, 230001, P.R. China.
- PMID: 35114924
- DOI: 10.2174/1568026622666220202123651
The oxadiazole core is considered a privileged moiety in many medicinal chemistry applications. The oxadiazole class includes 1,2,3-oxadiazole, 1,2,4-oxadiazole, 1,3,4-oxadiazole, and 1,2,5-oxadiazole. Compounds bearing an oxadiazole ring show a wide range of biological activities, such as anticancer, antibacterial, anti-inflammatory, anti-malarial, and insecticidal properties. Among oxadiazoles, the 1,3,4-oxadiazole has been the most widely explored moiety in medicinal chemistry research. This review is primarily focused on the anticancer, antibacterial, and anti-inflammatory activities of compounds containing 1,2,4-oxadiazole, 1,3,4-oxadiazole and 1,2,5-oxadiazole reported in the last five years.
Keywords: Anti-inflammatory; Antibacterial; Anticancer; Heterocyclic compounds; Oxadiazole; SAR.
Copyright© Bentham Science Publishers; For any queries, please email at [email protected]
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Current Topics in Medicinal Chemistry
Editor-in-Chief: Jia Zhou Chemical Biology Program Department of Pharmacology and Toxicology University of Texas Medical Branch Galveston TX USA
ISSN (Print): 1568-0266 ISSN (Online): 1873-4294
A Review of the Biological Activities of Heterocyclic Compounds Comprising Oxadiazole Moieties
- Key Lab of Biofabrication of Anhui Higher Education, Hefei University, Hefei, 230601, P.R. China
- School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, P.R. China
- Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia
- Institute of Tobacoo Research, Anhui Academy of Agricultural Sciences, Hefei, 230001, P.R. China
Volume 22, Issue 7, 2022
Published on: 02 March, 2022
Page: [578 - 599] Pages: 22
DOI: 10.2174/1568026622666220202123651
The oxadiazole core is considered a privileged moiety in many medicinal chemistry applications. The oxadiazole class includes 1,2,3-oxadiazole, 1,2,4-oxadiazole, 1,3,4-oxadiazole, and 1,2,5-oxadiazole. Compounds bearing an oxadiazole ring show a wide range of biological activities, such as anticancer, antibacterial, anti-inflammatory, anti-malarial, and insecticidal properties. Among oxadiazoles, the 1,3,4-oxadiazole has been the most widely explored moiety in medicinal chemistry research. This review is primarily focused on the anticancer, antibacterial, and anti-inflammatory activities of compounds containing 1,2,4-oxadiazole, 1,3,4-oxadiazole and 1,2,5-oxadiazole reported in the last five years.
Keywords: Heterocyclic compounds , Oxadiazole , Anticancer , Antibacterial , Anti-inflammatory , SAR.
Graphical Abstract
Title: A Review of the Biological Activities of Heterocyclic Compounds Comprising Oxadiazole Moieties
Volume: 22 Issue: 7
Author(s): Ban-Feng Ruan, Qing-Lei Guo, Qing-Shan Li, Lu-Zhi Li, Girdhar Singh Deora*Ben-Guo Zhou*
Abstract: The oxadiazole core is considered a privileged moiety in many medicinal chemistry applications. The oxadiazole class includes 1,2,3-oxadiazole, 1,2,4-oxadiazole, 1,3,4-oxadiazole, and 1,2,5-oxadiazole. Compounds bearing an oxadiazole ring show a wide range of biological activities, such as anticancer, antibacterial, anti-inflammatory, anti-malarial, and insecticidal properties. Among oxadiazoles, the 1,3,4-oxadiazole has been the most widely explored moiety in medicinal chemistry research. This review is primarily focused on the anticancer, antibacterial, and anti-inflammatory activities of compounds containing 1,2,4-oxadiazole, 1,3,4-oxadiazole and 1,2,5-oxadiazole reported in the last five years.
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Ruan Ban-Feng, Guo Qing-Lei, Li Qing-Shan, Li Lu-Zhi, Deora Girdhar Singh*, Zhou Ben-Guo*, A Review of the Biological Activities of Heterocyclic Compounds Comprising Oxadiazole Moieties, Current Topics in Medicinal Chemistry 2022; 22(7) . https://dx.doi.org/10.2174/1568026622666220202123651
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Arabian Journal of Chemistry
Review synthesis and biological significances of 1,3,4-thiadiazolines and related heterocyclic compounds.
This review article describes the survey of literature regarding the variety of synthetic methods of 1,3,4-thiadiazoline and related compounds in the last seven years (2004–2010). The aim of the review is to find out different methods for the synthesis of thiadiazolines. These heterocyclics are majorly obtained from the cyclization reactions of thiosemicarbazone under the various conditions. From the literature studies it was found that major importance was given to their pharmaceutical significance i.e., regarding their biological activity against different fungal and bacterial strains.
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A comprehensive review of bioactive peptides from marine fungi and their biological significance.
Graphical Abstract
1. Introduction
2. bioactive peptides in particular fungal genera, 2.1. acremonium, 2.2. ascotricha, 2.3. aspergillus, 2.4. asteromyces, 2.5. ceratodictyon, 2.6. clonostachys, 2.7. emericella, 2.8. exserohilum, 2.9. microsporum, 2.10. metarrhizium, 2.11. penicillium, 2.12. scytalidium, 2.13. simplicillium, 2.14. stachylidium, 2.15. talaromyces, 2.16. trichoderma, 2.17. zygosporium, 3. discussion and general perspectives, 4. conclusions, author contributions, acknowledgments, conflicts of interest.
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Share and Cite
Youssef, F.S.; Ashour, M.L.; Singab, A.N.B.; Wink, M. A Comprehensive Review of Bioactive Peptides from Marine Fungi and Their Biological Significance. Mar. Drugs 2019 , 17 , 559. https://doi.org/10.3390/md17100559
Youssef FS, Ashour ML, Singab ANB, Wink M. A Comprehensive Review of Bioactive Peptides from Marine Fungi and Their Biological Significance. Marine Drugs . 2019; 17(10):559. https://doi.org/10.3390/md17100559
Youssef, Fadia S., Mohamed L. Ashour, Abdel Nasser B. Singab, and Michael Wink. 2019. "A Comprehensive Review of Bioactive Peptides from Marine Fungi and Their Biological Significance" Marine Drugs 17, no. 10: 559. https://doi.org/10.3390/md17100559
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